Lu-PSMA for Oligometastatic Prostate Cancer Treated With STereotactic Ablative Radiotherapy, a Randomised Phase II Parallel Cohort Trial
The aim of this study is to assess the progression free survival (PFS) of SABR alone and SABR + 177Lu-prostate-specific membrane antigen (PSMA) in patients with oligometastatic prostate cancer undergoing PSMA positron emission tomography (PET) staging.
• Male aged 18 years or older at screening
• Patient has provided written informed consent
• Histologically confirmed prostate adenocarcinoma w
• Prior definitive treatment of the primary with either curative intent radiotherapy and/or surgery
• Patient has 1-5 sites of nodal or bony metastases on 68Ga-PSMA or 18F-DCFPyL PET/CT
• Adequate haematological function as defined by:
‣ Absolute neutrophil count (ANC) ≥1.5 x 109/L
⁃ Platelet count \>150x 109/L
⁃ Haemoglobin ≥100 g/L
⁃ Creatinine Clearance ≥ 40mL/min (Cockcroft-Gault formula)
• Assessed as suitable for SABR by a radiation oncologist
• Patients must agree to use an adequate method of contraception
• Have a performance status of 0-1 on the ECOG Performance Scale